Royal Air Force Typhoon jets have operated alongside France's air force in a coordinated attack targeting an hidden munitions depot in Syrian territory employed by the IS group, per a report from the UK Ministry of Defence.
The site, pinpointed through reconnaissance, was thought to be storing arms and explosives, the announcement noted, and was situated in mountains just above the ancient city of Palmyra in central Syria.
"Our aircraft utilized laser-guided Paveway IV weapons to target a several approach shafts leading to the facility... initial indications suggest the strike was effective," the ministry announced.
There was no evidence of any civilian impact in the strike conducted Saturday night and every plane involved made a safe return, the MoD added.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as Daesh - enforced militant control over significant areas in Syria and Iraq until 2019.
"This action demonstrates our UK leadership, and determination to stand shoulder to shoulder with our partners, to stamp out any revival of the terrorist group and their violent and radical beliefs in the area," the British Defence Secretary John Healey said.
British military aircraft have conducted overwatch operations over Syrian airspace to "forestall any attempted comeback" of IS following its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to every member of British forces participating in this mission for their expertise and their courage," he added. "They were among thousands of UK service members deployed over Christmas and New Year. This action, to eliminate terrorist threats who endanger our safety, highlights how British military are ready to step up, all year round, keeping Britain secure domestically and strong abroad."
In December, the United States armed forces executed what it termed a "massive strike" against Daesh sites in the country, after an assault killed two US servicemembers and a civilian interpreter in Palmyra.
The UN says IS still boasts roughly 5-7 thousand combatants in Syria and Iraq.